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uKnow Peanut FAQ's

To make it easier to use the ImmunoCAP Peanuts FAQ section has been
broken down by categories. Choose a category to get started.


1. What is Allergen Component Testing?

Allergen component testing is a new technology that pinpoints sensitization to specific allergen components (proteins) of a substance that may be causing a patient’s symptoms.

2. How does Allergen Component Testing help physicians?

Allergen Component Testing helps the physician:
  1. Identify primary, species-specific, allergen components (proteins) that cause allergic sensitization in patients
  2. Assess the patient’s risk of an allergic reaction to those proteins found in certain foods
  3. Provide clarity regarding the patient’s risk of allergic reaction to ease fears and help target effective management: ensure relevant dietary modifications and medications, determine appropriateness of a patient for oral food challenge testing

3. What are ImmunoCAP Peanut Component Tests?

The ImmunoCAP Allergen Component tests are a group of tests, carefully selected to evaluate peanut IgE sensitization patterns at the protein level. This level of detail allows the clinician to assess the patient’s risk of allergic reaction and to differentiate between symptoms caused by cross-reactive proteins verses primary, species-specific proteins.

4. Are there any additional ImmunoCAP Component Allergen Tests available?

ImmunoCAP Component Tests are commercially available for peanuts, cow’s milk and hen’s egg. Additional tests to common allergens are currently being researched and developed through the Phadia Immunology Reference Laboratory Center for Innovation.
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5. How do ImmunoCAP Peanut Component Tests help patients?

ImmunoCAP Peanut Component Tests offer physicians a new level of detail compared with current tests. Nearly 1 out of 4 children sensitized to whole peanut has a high risk for systemic reaction. A majority of children sensitized to peanut are not clinically allergic to peanuts.1

Results from the ImmunoCAP Peanut Component tests may bring clarity to an often uncertain diagnosis. Many children live restricted lives because they are told they have a peanut allergy. Parents and kids live with the uncertainty and fear of a systemic allergic reaction.

The ImmunoCAP Peanut Component Tests Tests help a physician to assess the patient’s level of risk of an allergic reaction, to guide relevant dietary modification to prevent unnecessary dietary restrictions, and may help to reassure patients when the risk for allergic symptoms is low or when they will most likely experience mild or localized reactions upon exposure to peanut.

1. Nicolaou et al. J Allergy Clin Immunol. 2010;125:191-197

6. How do ImmunoCAP Peanut Component Tests help physicians?

The ImmunoCAP Peanut Component Tests help physicians:
  1. Identify if a patient has antibodies to the components (proteins) in the peanut responsible for the most severe reactions.
  2. Identify if a patient has antibodies to other components (proteins) that may be less likely to cause a severe reaction.
  3. Help to determine the true risk of a severe allergic reaction—giving parents and doctors the information they need to make better-informed decisions about managing peanut allergy.

7. Why order ImmunoCAP Peanut Component Tests if the patient knows they have symptoms when exposed to peanut?

The ImmunoCAP Peanut Component Tests help identify antibodies to the components (proteins) in the peanut responsible for the most severe reactions as well as antibodies to other components that may be less likely to cause a severe reaction. The test results help provide greater clarity and allow for a plan of action for the physician and the patient.

8. Are other peanut tests available outside of the ImmunoCAP Peanut Component Tests?

Conventional allergy diagnostic testing such blood testing, skin prick testing and oral food challenges are available to test a patient’s sensitivity to whole peanut. The ImmunoCAP Peanut Component Tests are the only tests that can identify a patient’s sensitization at the component (protein) level to determine risk of a systemic allergic reaction to peanut.
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9. Are the ImmunoCAP Peanut Component Tests covered by insurance?

The tests are covered, at least partially, by most insurance plans. Patients may use a flexible spending account benefit if it is available to them to help defray any out-of-pocket costs
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10. How do the test reults help physicians and patients better understand peanut allergy?

Both positive and negative results provide value to the patient and physician.

Negative results allow the physician to explore appropriate treatment options and to consider different underlying causes of the patient’s symptoms. Negative results reassure patients they will most likely experience mild or localized reactions upon exposure to peanut and may prevent unnecessary dietary restrictions.

Positive results help the physician to assess the patient’s level of risk for a severe allergic reaction, to direct relevant dietary modification and to develop a personalized treatment plan tailored to the patient’s sensitization pattern. Positive results allow parents to develop appropriate safeguards to protect their child.
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